Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus

Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus

Abstract Background The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hippocampus. This diminishing noradrenaline availability...

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Bibliographic Details
Main Authors: Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, Yasuyuki Kimura
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:EJNMMI Research
Subjects:
Noradrenaline
Noradrenaline Transporter
[11C]MRB
DSP-4
Positron emission tomography
Brain
Online Access:https://doi.org/10.1186/s13550-023-01032-y

Internet

https://doi.org/10.1186/s13550-023-01032-y

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