Trio-Drug Combination of Sodium Valproate, Baclofen and Thymoquinone Exhibits Synergistic Anticonvulsant Effects in Rats and Neuro-Protective Effects in HEK-293 Cells

Trio-Drug Combination of Sodium Valproate, Baclofen and Thymoquinone Exhibits Synergistic Anticonvulsant Effects in Rats and Neuro-Protective Effects in HEK-293 Cells

Epilepsy is a chronic brain disorder, with anti-epileptic drugs (AEDs) providing relief from hyper-excitability of neurons, but largely failing to restrain neurodegeneration. We investigated a progressive preclinical trial in rats, whereby the test drugs; sodium valproate (SVP; 150 and 300 mg/kg), b...

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Bibliographic Details
Main Authors: Faheem Hyder Pottoo, Mohammed Salahuddin, Firdos Alam Khan, Batool Taleb Albaqshi, Mohamed S. Gomaa, Fatima S. Abdulla, Noora AlHajri, Mohammad N. Alomary
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Current Issues in Molecular Biology
Subjects:
epilepsy
sodium valproate
baclofen
thymoquinone
HEK-293 cells
neuroprotection
Online Access:https://www.mdpi.com/1467-3045/44/10/299

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https://www.mdpi.com/1467-3045/44/10/299

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