EGFR Activation Impairs Antiviral Activity of Interferon Signaling in Brain Microvascular Endothelial Cells During Japanese Encephalitis Virus Infection

EGFR Activation Impairs Antiviral Activity of Interferon Signaling in Brain Microvascular Endothelial Cells During Japanese Encephalitis Virus Infection

The establishment of Japanese encephalitis virus (JEV) infection in brain microvascular endothelial cells (BMECs) is thought to be a critical step to induce viral encephalitis with compromised blood–brain barrier (BBB), and the mechanisms involved in this process are not completely understood. In th...

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Bibliographic Details
Main Authors: Ya-Ge Zhang, Hao-Wei Chen, Hong-Xin Zhang, Ke Wang, Jie Su, Yan-Ru Chen, Xiang-Ru Wang, Zhen-Fang Fu, Min Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
Japanese encephalitis virus
human brain microvascular endothelial cells
epidermal growth factor receptor
interferon
ERK
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.894356/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.894356/full

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