Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons

Neurons communicate by regulated secretion of chemical signals from synaptic vesicles (SVs) and dense-core vesicles (DCVs). Here, we investigated the maturation of these two secretory pathways in micro-networks of human iPSC-derived neurons. These micro-networks abundantly expressed endogenous SV an...

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Bibliographic Details
Main Authors: Javier Emperador Melero, Aishwarya G. Nadadhur, Desiree Schut, Jan V. Weering, Vivi M. Heine, Ruud F. Toonen, Matthijs Verhage
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Reports
Subjects:
regulated neurosecretion
human iPSC-derived neurons
dense-core vesicles
neuropeptides
synaptic transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117300358

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http://www.sciencedirect.com/science/article/pii/S2213671117300358

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