Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth

Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth

Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor coactivator 4 (NCOA4) was recently identified as a cargo receptor in ferritin degradation. Here, we show that Mtb infection enh...

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Bibliographic Details
Main Authors: Youchao Dai, Chuanzhi Zhu, Wei Xiao, Kaisong Huang, Xin Wang, Chenyan Shi, Dachuan Lin, Huihua Zhang, Xiaoqian Liu, Bin Peng, Yi Gao, Cui Hua Liu, Baoxue Ge, Stefan H.E. Kaufmann, Carl G. Feng, Xinchun Chen, Yi Cai
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-04-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/JCI159941

Internet

https://doi.org/10.1172/JCI159941

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