Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging

Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging

Abstract Background The extracellular localisation of the Heat shock protein 90 (Hsp90) is associated with the diseased state and wound healing and presents a promising opportunity for cancer targeting using Positron Emission Tomography (PET) imaging and molecularly targeted radiotherapy. The aim of...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Valeria Narykina, Janke Kleynhans, Christopher Cawthorne, Joost Schymkowitz, Frederic Rousseau, Guy Bormans
Format: Artikel
Sprache:English
Veröffentlicht: SpringerOpen 2025-02-01
Schriftenreihe:EJNMMI Radiopharmacy and Chemistry
Schlagworte:
Hsp90
Nanobodies
PET imaging
Gallium-68
Cancer
Diagnostics
Online Zugang:https://doi.org/10.1186/s41181-025-00331-0

Online

https://doi.org/10.1186/s41181-025-00331-0

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