IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma

IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma

Abstract Background Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma often resistant to chemotherapy. Serum level of soluble IL-2 receptor α (IL-2Rα) is elevated in NKTCL patients and correlates significantly with treatment response and survival. In the current stud...

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Bibliographic Details
Main Authors: Liang Wang, Xi-wen Bi, Yu-jia Zhu, Ying-zhi He, Qiu-yu Lai, Zhong-jun Xia, Qing-qing Cai
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Cancer Communications
Subjects:
Natural killer/T-cell lymphoma
Latent membrane protein 1
Epstein–Barr virus
Interleukin-2 receptor alpha
Online Access:http://link.springer.com/article/10.1186/s40880-018-0334-8

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http://link.springer.com/article/10.1186/s40880-018-0334-8

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