Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis

Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis

Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear receptor that functions to maintain metabolic homeostasis, regulate cell growth, and limit the development of excessive inflammation during immune responses. Previously, we reported that PPAR-δ-deficient mice develop a more severe clin...

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Bibliographic Details
Main Authors: Ellinore R. Doroshenko, Paulina C. Drohomyrecky, Annette Gower, Heather Whetstone, Lindsay S. Cahill, Milan Ganguly, Shoshana Spring, Tae Joon Yi, John G. Sled, Shannon E. Dunn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
microglia
experimental autoimmune encephalomyelitis
axon injury
neuroinflammation
peroxisome proliferator-activated receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.570425/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.570425/full

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