Enhanced Bacteremia in Dextran Sulfate-Induced Colitis in Splenectomy Mice Correlates with Gut Dysbiosis and LPS Tolerance

Enhanced Bacteremia in Dextran Sulfate-Induced Colitis in Splenectomy Mice Correlates with Gut Dysbiosis and LPS Tolerance

Because both endotoxemia and gut dysbiosis post-splenectomy might be associated with systemic infection, the susceptibility against infection was tested by dextran sulfate solution (DSS)-induced colitis and lipopolysaccharide (LPS) injection models in splenectomy mice with macrophage experiments. He...

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Bibliographic Details
Main Authors: Arthid Thim-Uam, Jiradej Makjaroen, Jiraphorn Issara-Amphorn, Wilasinee Saisorn, Dhammika Leshan Wannigama, Wiwat Chancharoenthana, Asada Leelahavanichkul
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
splenectomy
gut barrier defect
endotoxemia
dysbiosis
Online Access:https://www.mdpi.com/1422-0067/23/3/1676

Internet

https://www.mdpi.com/1422-0067/23/3/1676

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