Targeting potassium channels and autophagy to defeat chemoresistance
Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1745038 |