Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity

Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity

BRD4 inhibitors have demonstrated promising potential in cancer therapy. However, their therapeutic efficacy in breast cancer varies depending on the breast cancer subtype, particularly in the treatment of TNBC. In this study, we designed and synthesized 94 derivatives of 4-(3-(3,5-dimethylisoxazol-...

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Bibliographic Details
Main Authors: Yingpeng Li, Xinhong Chu, Yu Yin, Hongkun Li, Hui Fu, Xinchi Feng, Yanru Deng, Jun Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
BRD4
PARP1
BRD4 inhibitor
breast cancer
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1289003/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1289003/full

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