Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis

Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis

In the present study, we assess tyrosol derivatives bearing 3,5-disubstituted isoxazoles and 1,4-disubstituted triazoles for their ability to inhibit the proliferation of K562 cells derived from leukemia as well as primary chronic myeloid leukemia (CML) cells obtained from the peripheral blood of 15...

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Bibliographic Details
Main Authors: Zaineb Abdelkafi-Koubaa, Imen Aissa, Hichem Ben Jannet, Najet Srairi-Abid, Naziha Marrakchi, Samia Menif
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
chronic myeloid leukemia
tyrosol
3,5-disubstituted isoxazole
1,4-disubstituted triazole
anti-proliferative activity
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/27/16/5086

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https://www.mdpi.com/1420-3049/27/16/5086

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