Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress

Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress

The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little is known about mechanisms responsible for atrial remodeling in AD pathogenesis. α7 nicotinic acetylcholine receptors (α7nAChR) has been shown to h...

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Bibliographic Details
Main Authors: Jikai Zhao, Liming Yu, Xiaodong Xue, Yinli Xu, Tao Huang, Dengyue Xu, Zhishang Wang, Linyu Luo, Huishan Wang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
α7nAChR
Atrial fibrillation
amyloid-β
Mitochondrial oxidative stress
Atrial remodeling
CaMKII
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003664

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http://www.sciencedirect.com/science/article/pii/S2213231722003664

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