Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion

Introduction: Genetic polymorphisms in TCF7L2 are the strongest common risk variants for type 2 diabetes mellitus (T2D). We and others have shown that genetic variation in TCF7L2 and WFS1 affect incretin-stimulated insulin secretion. A recent genome-wide association study discovered genetic variants...

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Bibliographic Details
Main Authors: Benjamin Assad Jaghutriz, Martin Heni, Stefan Zoltán Lutz, Louise Fritsche, Fausto Machicao, Harald Staiger, Andreas Peter, Hans-Ulrich Häring, Andreas Fritsche, Róbert Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
gene x gene interactions
SNP x SNP interactions
TCF7L2
WFS1
incretin resistance
incretins
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00072/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00072/full

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