Reduced alphabet of prebiotic amino acids optimally encodes the conformational space of diverse extant protein folds

Reduced alphabet of prebiotic amino acids optimally encodes the conformational space of diverse extant protein folds

Abstract Background There is wide agreement that only a subset of the twenty standard amino acids existed prebiotically in sufficient concentrations to form functional polypeptides. We ask how this subset, postulated as {A,D,E,G,I,L,P,S,T,V}, could have formed structures stable enough to found metab...

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Bibliographic Details
Main Author: Armando D. Solis
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Evolutionary Biology
Subjects:
Prebiotic amino acids
Proteogenesis
Protein evolution
Protein structure
Protein backbone conformation
Residue contacts
Online Access:http://link.springer.com/article/10.1186/s12862-019-1464-6

Internet

http://link.springer.com/article/10.1186/s12862-019-1464-6

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