Reduced alphabet of prebiotic amino acids optimally encodes the conformational space of diverse extant protein folds
Abstract Background There is wide agreement that only a subset of the twenty standard amino acids existed prebiotically in sufficient concentrations to form functional polypeptides. We ask how this subset, postulated as {A,D,E,G,I,L,P,S,T,V}, could have formed structures stable enough to found metab...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Evolutionary Biology |
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| Online Access: | http://link.springer.com/article/10.1186/s12862-019-1464-6 |