Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo

Abstract Background Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the interaction between oxidatively stressed red blood cells (RBC) and cerebral endothelium may underlie CMH development. However, the real-time examinat...

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Bibliographic Details
Main Authors: Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher, Xiangmin Xu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-023-02932-5