Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/3 mediated retraction of granulosa cell filop...

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Bibliographic Details
Main Authors: Laleh Abbassi, Stephany El-Hayek, Karen Freire Carvalho, Wusu Wang, Qin Yang, Sofia Granados-Aparici, Rafael Mondadori, Vilceu Bordignon, Hugh J. Clarke
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21644-z

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https://doi.org/10.1038/s41467-021-21644-z

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