Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis

Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis

Abstract Abnormal kidney development leads to lower nephron number, predisposing to renal diseases in adulthood. In embryonic kidneys, nephron endowment is dictated by the availability of nephron progenitors, whose self-renewal and differentiation require a relatively repressed chromatin state. More...

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Bibliographic Details
Main Authors: Luca Perico, Marina Morigi, Anna Pezzotta, Daniela Corna, Valerio Brizi, Sara Conti, Cristina Zanchi, Fabio Sangalli, Piera Trionfini, Sara Buttò, Christodoulos Xinaris, Susanna Tomasoni, Carlamaria Zoja, Giuseppe Remuzzi, Ariela Benigni, Barbara Imberti
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03039-8

Internet

https://doi.org/10.1038/s41598-021-03039-8

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