The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated with T1D is in the interferon-induced helicase C domai...

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Bibliographic Details
Main Authors: Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, Jacquelyn A. Gorman
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
IFIH1
MDA5
type I interferons
T cells
diabetes
insulitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1349601/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1349601/full

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