Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol

Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol

Allogeneic Natural Killer (NK) cells are used for adoptive immunotherapy after stem cell transplantation. In order to overcome technical limitations in NK cell purification and activation, the following study investigates the impact of different variables on NK cell recovery, cytotoxicity and T cell...

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Bibliographic Details
Main Authors: Ulrike eKoehl, Claudia eBrehm, Sabine eHuenecke, Stephan eKloess, Melanie eBremm, Stefanie Yvonne eZimmermann, Evelyn eUllrich, Jan eSoerensen, Andrea eQuaiser, Stephanie eErben, Claudia eWunram, Tanja eGardlowski, Eileen eAuth, Torsten eTonn, Chritian eSeidl, Sandrine eMeyer-Monard, Martin eStern, Jakob ePassweg, Thomas eKlingebiel, Peter eBader, Dirk eSchwabe, Ruth eEsser
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Oncology
Subjects:
Cytotoxicity
NK cell expansion
NK cell purification
IL-2 activation
T cell removal
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00118/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00118/full

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