Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through <i>palladium</i>-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was...

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Bibliographic Details
Main Authors: Rodrigo Santos Aquino de Araújo, Julianderson de Oliveira dos Santos Carmo, Simone Lara de Omena Silva, Camila Radelley Azevedo Costa da Silva, Tayhana Priscila Medeiros Souza, Natália Barbosa de Mélo, Jean-Jacques Bourguignon, Martine Schmitt, Thiago Mendonça de Aquino, Renato Santos Rodarte, Ricardo Olímpio de Moura, José Maria Barbosa Filho, Emiliano Barreto, Francisco Jaime Bezerra Mendonça-Junior
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
anticancer activity
lung cancer
non-small-cell lung cancer
epithelial–mesenchymal transition
metastasis
coumarin derivative
Online Access:https://www.mdpi.com/1424-8247/15/1/104

Internet

https://www.mdpi.com/1424-8247/15/1/104

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