Unleashing a novel function of Endonuclease G in mitochondrial genome instability

Unleashing a novel function of Endonuclease G in mitochondrial genome instability

Having its genome makes the mitochondrion a unique and semiautonomous organelle within cells. Mammalian mitochondrial DNA (mtDNA) is a double-stranded closed circular molecule of about 16 kb coding for 37 genes. Mutations, including deletions in the mitochondrial genome, can culminate in different h...

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Bibliographic Details
Main Authors: Sumedha Dahal, Humaira Siddiqua, Shivangi Sharma, Ravi K Babu, Diksha Rathore, Sheetal Sharma, Sathees C Raghavan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
tetraplexes
mitochondrial fragility
Endo G
double-strand breaks
MMEJ
mitochondrial deletion
Online Access:https://elifesciences.org/articles/69916

Internet

https://elifesciences.org/articles/69916

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