Regional transcriptional vulnerability to basal forebrain functional dysconnectivity in mild cognitive impairment patients

Regional transcriptional vulnerability to basal forebrain functional dysconnectivity in mild cognitive impairment patients

Nucleus basalis of Meynert (NbM), one of the earliest targets of Alzheimer's disease (AD), may act as a seed for pathological spreading to its connected regions. However, the underlying basis of regional vulnerability to NbM dysconnectivity remains unclear. NbM functional dysconnectivity was as...

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Bibliographic Details
Main Authors: Peng Ren, Wencai Ding, Siyang Li, Guiyou Liu, Meng Luo, Wenyang Zhou, Rui Cheng, Yiqun Li, Pingping Wang, Zhipeng Li, Lifen Yao, Qinghua Jiang, Xia Liang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neurobiology of Disease
Subjects:
Nucleus basalis of Meynert
Functional connectivity
Mild cognitive impairment
Basal forebrain
Transcriptional vulnerability
Tissue-specific geneset risk score
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122003758

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http://www.sciencedirect.com/science/article/pii/S0969996122003758

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