PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications

PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications

The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo. The study employed gene editing of PHRU through si...

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Bibliographic Details
Main Authors: Wang Xiangyan, Lu Hao, Rong Jun, Sun Zhongjie, Zheng Yanhua, Fan Bolin, Jia Ziming
Format: Article
Language:English
Published: De Gruyter 2024-01-01
Series:Open Life Sciences
Subjects:
urate oxidase
protein expression and purification
pegylation
preclinical test
Online Access:https://doi.org/10.1515/biol-2022-0799

Internet

https://doi.org/10.1515/biol-2022-0799

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