The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome

The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome

The influenza virus genome forms viral ribonucleoprotein (vRNP) complexes with nucleoprotein and viral RNA-dependent RNA polymerases (RdRp), PB1, PB2, and PA subunits. The vRNP complex catalyzes both genome replication and transcription reactions. PB1 contains the motifs highly conserved among RdRps...

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Bibliographic Details
Main Authors: Nguyen Trong Binh, Chitose eWakai, Atsushi eKawaguchi, Kyosuke eNagata
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Microbiology
Subjects:
replication
transcription
Influenza Virus
promoter binding
reverse-genetics
RNA-dependent RNA polymerase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00398/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00398/full

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