Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis

Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis

Abstract Background The biological mechanisms underlying the differential response to abatacept in patients with rheumatoid arthritis (RA) are unknown. Here, we aimed to identify cellular, transcriptomic, and proteomic features that predict resistance to abatacept in patients with RA. Methods Blood...

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Bibliographic Details
Main Authors: Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu, Motomu Hashimoto
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Abatacept
Multi-omics
Monocyte
TLR5
MYD88
Online Access:https://doi.org/10.1186/s13075-023-03236-y

Internet

https://doi.org/10.1186/s13075-023-03236-y

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