A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells

A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells

Glioblastoma multiforme (GBM) is a grade IV, highly malignant brain tumor. Because of the heterogeneity of GBM, a multitarget drug is a rational strategy for GBM treatment. Histone deacetylase inhibitors (HDACis) regulate the expression of numerous genes involved in cell death, apoptosis, and tumori...

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Bibliographic Details
Main Authors: Hui Hua Chang, Yao-Yuan Chang, Bing-Chen Tsai, Li-Jyun Chen, An-Chi Chang, Jian-Ying Chuang, Po-Wu Gean, Yuan-Shuo Hsueh
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
Glioblastoma multiforme
drug resistance
selective HDAC inhibitor
LMK235
RNA-seq
SCNN1A
Online Access:https://www.mdpi.com/2072-6694/14/18/4537

Internet

https://www.mdpi.com/2072-6694/14/18/4537

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