Measurement of 17-Hydroxyprogesterone by LCMSMS Improves Newborn Screening for CAH Due to 21-Hydroxylase Deficiency in New Zealand

Measurement of 17-Hydroxyprogesterone by LCMSMS Improves Newborn Screening for CAH Due to 21-Hydroxylase Deficiency in New Zealand

The positive predictive value of newborn screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency was <2% in New Zealand. This is despite a bloodspot second-tier immunoassay method for 17-hydroxyprogesterone measurement with an additional solvent extract step to reduce th...

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Bibliographic Details
Main Authors: Mark R de Hora, Natasha L Heather, Tejal Patel, Lauren G Bresnahan, Dianne Webster, Paul L Hofman
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Neonatal Screening
Subjects:
congenital adrenal hyperplasia
17-hydroxyprogesterone
newborn screening
liquid chromatography tandem mass spectrometry
Online Access:https://www.mdpi.com/2409-515X/6/1/6

Internet

https://www.mdpi.com/2409-515X/6/1/6

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