Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin

Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin

To overcome yearly efforts and costs for the production of seasonal influenza vaccines, new approaches for the induction of broadly protective and long-lasting immune responses have been developed in the past decade. To warrant safety and efficacy of the emerging crossreactive vaccine candidates, it...

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Bibliographic Details
Main Authors: Nastasja C. Hauck, Josiane Kirpach, Christina Kiefer, Sophie Farinelle, Sophie Maucourant, Stephen A. Morris, William Rosenberg, Feng Q. He, Claude P. Muller, I-Na Lu
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Viruses
Subjects:
influenza
next generation sequencing
unique molecular identifiers
virus evolution
immune selection
immune pressure
bottleneck effect
vaccine
Online Access:http://www.mdpi.com/1999-4915/10/4/148

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http://www.mdpi.com/1999-4915/10/4/148

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