The clonal structure and dynamics of the human T cell response to an organic chemical hapten

The clonal structure and dynamics of the human T cell response to an organic chemical hapten

Diphenylcyclopropenone (DPC) is an organic chemical hapten which induces allergic contact dermatitis and is used in the treatment of warts, melanoma, and alopecia areata. This therapeutic setting therefore provided an opportunity to study T cell receptor (TCR) repertoire changes in response to hapte...

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Bibliographic Details
Main Authors: Tahel Ronel, Matthew Harries, Kate Wicks, Theres Oakes, Helen Singleton, Rebecca Dearman, Gavin Maxwell, Benny Chain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
T cell receptor
repertoire
contact dermatitis
patch test
cdr3 motif
Bayesian network
Online Access:https://elifesciences.org/articles/54747

Internet

https://elifesciences.org/articles/54747

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