Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma.

Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma.

Ewing sarcoma is the second most common bone cancer in children, and while patients who present with metastatic disease at the time of diagnosis have a dismal prognosis. Ewing sarcoma tumors are driven by the fusion gene EWS/Fli1, and while these tumors are genetically homogenous, the transcriptiona...

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Bibliographic Details
Main Authors: Ryota Shirai, Tyler Biebighauser, Deandra Walker, Jillian Oviedo, Sarah Nelson-Taylor, Avery Bodlak, Timothy Porfilio, Naoki Oike, Andrew Goodspeed, Masanori Hayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0305490

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https://doi.org/10.1371/journal.pone.0305490

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