Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis

Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis

Abstract Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-treated rats and patients with PF and analysed the eff...

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Bibliographic Details
Main Authors: Christina Hesse, Valerie Beneke, Sebastian Konzok, Claudia Diefenbach, Jannie Marie Bülow Sand, Sarah Rank Rønnow, Morten Asser Karsdal, Danny Jonigk, Katherina Sewald, Armin Braun, Diana Julie Leeming, Lutz Wollin
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Respiratory Research
Subjects:
Antifibrotic therapy
Collagen
Extracellular matrix
Human lung
Precision-cut lung slices
Neoepitope biomarkers
Online Access:https://doi.org/10.1186/s12931-022-02116-4

Internet

https://doi.org/10.1186/s12931-022-02116-4

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