12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes

12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes

Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1 diabetes (T1D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of proinflammatory eicosanoids, but its role and mechanisms in myeloid cells in the pathogenesis of isl...

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Bibliographic Details
Main Authors: Abhishek Kulkarni, Annie R. Pineros, Melissa A. Walsh, Isabel Casimiro, Sara Ibrahim, Marimar Hernandez-Perez, Kara S. Orr, Lindsey Glenn, Jerry L. Nadler, Margaret A. Morris, Sarah A. Tersey, Raghavendra G. Mirmira, Ryan M. Anderson
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-07-01
Series:JCI Insight
Subjects:
Autoimmunity
Endocrinology
Online Access:https://doi.org/10.1172/jci.insight.147812

Internet

https://doi.org/10.1172/jci.insight.147812

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