IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

Abstract Background Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed. However, endogenous NSCs in the adult spinal cord differentiate into m...

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Bibliographic Details
Main Authors: Jingyu Wang, Lintao Xu, Deqing Peng, Yongjian Zhu, Zhaowen Gu, Ying Yao, Heyangzi Li, Xi Cao, Chun-yan Fu, Mingzhi Zheng, Xinghui Song, Yueming Ding, Yueliang Shen, Jinjie Zhong, Ying-ying Chen, Jue Hu, Lin-lin Wang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Inflammation and Regeneration
Subjects:
CD8 (+) T cells
Spinal cord injury
Neural stem cell
Interferon-γ
Astrocyte
Online Access:https://doi.org/10.1186/s41232-023-00263-9

Internet

https://doi.org/10.1186/s41232-023-00263-9

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