Water-Soluble Products of Photooxidative Destruction of the Bisretinoid A2E Cause Proteins Modification in the Dark

Water-Soluble Products of Photooxidative Destruction of the Bisretinoid A2E Cause Proteins Modification in the Dark

Aging of the retina is accompanied by a sharp increase in the content of lipofuscin granules and bisretinoid A2E in the cells of the retinal pigment epithelium (RPE) of the human eye. It is known that A2E can have a toxic effect on RPE cells. However, the specific mechanisms of the toxic effect of A...

Full description

Bibliographic Details
Main Authors: Alexander Dontsov, Marina Yakovleva, Natalia Trofimova, Natalia Sakina, Alexander Gulin, Arseny Aybush, Fedor Gostev, Alexander Vasin, Tatiana Feldman, Mikhail Ostrovsky
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
retinal pigment epithelium
A2E
lipofuscin granules
fluorophores
photooxidation
carbonyls
Online Access:https://www.mdpi.com/1422-0067/23/3/1534

Internet

https://www.mdpi.com/1422-0067/23/3/1534

Similar Items