Mechanism of action and neuroprotective role of nicorandil in ischemic stroke

Mechanism of action and neuroprotective role of nicorandil in ischemic stroke

Nicorandil is a dual mechanism anti-anginal agent that acts as a nitric oxide (NO) donor and a potassium (K+) channel opener. Recent studies have evaluated the effect of nicorandil on ischemic stroke. Neurons have a low tolerance to hypoxia and therefore the brain tissue is significantly vulnerable...

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Bibliographic Details
Main Authors: Maryam Owjfard, Negin Rahmani, Arashk Mallahzadeh, Mahnaz Bayat, Afshin Borhani-Haghighi, Farzaneh Karimi, Mohammad Reza Namavar
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Ischemic stroke
Nicorandil
K+ channels
Nitric-oxide
Blood pressure
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024026719

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http://www.sciencedirect.com/science/article/pii/S2405844024026719

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