Population Pharmacokinetic Modeling of a Desmopressin Oral Lyophilisate in Growing Piglets as a Model for the Pediatric Population

Population Pharmacokinetic Modeling of a Desmopressin Oral Lyophilisate in Growing Piglets as a Model for the Pediatric Population

Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric population, despite the lack of full PK studies in this population. A full PK study was per...

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Bibliographic Details
Main Authors: Elke Gasthuys, An Vermeulen, Siska Croubels, Joske Millecam, Stijn Schauvliege, Thomas van Bergen, Pauline De Bruyne, Johan Vande Walle, Mathias Devreese
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
piglet
animal model
pharmacokinetics
desmopressin
pediatric
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00041/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00041/full

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