Bipolar Patient–Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor

Bipolar Patient–Specific In Vitro Diagnostic Test Reveals Underlying Cardiac Arrhythmia Phenotype Caused by Calcium Channel Genetic Risk Factor

A common genetic risk factor for bipolar disorder is CACNA1C, a gene that is also critical for cardiac rhythm. The impact of CACNA1C mutations on bipolar patient cardiac rhythm is unknown. Here, we report the cardiac electrophysiological implications of a bipolar disorder–associated genetic risk fac...

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Bibliographic Details
Main Authors: Rachel Dow, Cindy DeLong, Guihua Jiang, Durga Attili, Jeffery Creech, Rachel Kraan, Katherine Campbell, Prakaimuk Saraithong, Sue O’Shea, Andre Monteiro da Rocha, Melvin G. McInnis, Todd J. Herron
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biological Psychiatry Global Open Science
Subjects:
Bipolar genetic risk factor
Cardiac electrophysiology
Induced pluripotent stem cells
Personalized medicine, Cardiac Regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324000090

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http://www.sciencedirect.com/science/article/pii/S2667174324000090

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