Evaluation of Neurofilament Light Chain as a Biomarker of Neurodegeneration in X-Linked Childhood Cerebral Adrenoleukodystrophy

Evaluation of Neurofilament Light Chain as a Biomarker of Neurodegeneration in X-Linked Childhood Cerebral Adrenoleukodystrophy

Cerebral adrenoleukodystrophy (CALD) is a devastating, demyelinating neuroinflammatory manifestation found in up to 40% of young males with an inherited mutation in <i>ABCD1</i>, the causative gene in adrenoleukodystrophy. The search for biomarkers which correlate to CALD disease burden...

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Bibliographic Details
Main Authors: Hongge Wang, Matthew D. Davison, Martin L. Kramer, Weiliang Qiu, Tatiana Gladysheva, Ruby M. S. Chiang, Can Kayatekin, David R. Nascene, Leyla A. Taghizadeh, Carina J. King, Erin E. Nolan, Ashish O. Gupta, Paul J. Orchard, Troy C. Lund
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
adrenoleukodystrophy
biomarkers
neurofilament light chain
Online Access:https://www.mdpi.com/2073-4409/11/5/913

Internet

https://www.mdpi.com/2073-4409/11/5/913

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