A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

<p>Abstract</p> <p>Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway....

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Bibliographic Details
Main Authors: Mellor James D, Brown Michael P, Irving Helen R, Zalcberg John R, Dobrovic Alexander
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Journal of Hematology & Oncology
Subjects:
FCGR2A
FCGR3A
trastuzumab
rituximab
cetuximab
ADCC
Online Access:http://www.jhoonline.org/content/6/1/1

Internet

http://www.jhoonline.org/content/6/1/1

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