A functional 12T-insertion polymorphism in the ATP1A1 promoter confers decreased susceptibility to hypertension in a male Sardinian population.

Identification of susceptibility genes for essential hypertension in humans has been a challenge due to its multifactorial pathogenesis complicated by gene-gene and gene-environment interactions, developmental programing and sex specific differences. These concurrent features make identification of...

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Main Authors: Victoria L Herrera, Khristine A Pasion, Ann Marie Moran, Roberta Zaninello, Maria Francesca Ortu, Giovanni Fresu, Daniela Antonella Piras, Giuseppe Argiolas, Chiara Troffa, Valeria Glorioso, Wanda Masala, Nicola Glorioso, Nelson Ruiz-Opazo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4304799?pdf=render