The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

Summary: Previous genetic and biological evidence converge on the involvement of synaptic dysfunction in schizophrenia, and OPCML, encoding a synaptic membrane protein, is reported to be genetically associated with schizophrenia. However, its role in the pathophysiology of schizophrenia remains larg...

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Bibliographic Details
Main Authors: Zhengrong Zhang, Maoqing Ye, Qiongwei Li, Yang You, Hao Yu, Yuanlin Ma, Liwei Mei, Xiaqin Sun, Lifang Wang, Weihua Yue, Rena Li, Jun Li, Dai Zhang
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719311532