Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study
BackgroundCausal research concerning the consumption of tea and the risk of chronic kidney disease (CKD) is limited. This study identified the potential causal effects of tea intake on CKD, the estimated glomerular filtration rate (eGFR), and albuminuria.MethodsGenome-wide association studies (GWASs...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.801591/full |
| _version_ | 1818320177341661184 |
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| author | Yangchang Zhang Yangchang Zhang Yangchang Zhang Yangchang Zhang Yang Xiong Shisi Shen Jialu Yang Jialu Yang Jialu Yang Wei Wang Wei Wang Wei Wang Tingting Wu Li Chen Qiuhua Yu Hangjia Zuo Xu Wang Xu Wang Xu Wang Xun Lei Xun Lei Xun Lei Xun Lei |
| author_facet | Yangchang Zhang Yangchang Zhang Yangchang Zhang Yangchang Zhang Yang Xiong Shisi Shen Jialu Yang Jialu Yang Jialu Yang Wei Wang Wei Wang Wei Wang Tingting Wu Li Chen Qiuhua Yu Hangjia Zuo Xu Wang Xu Wang Xu Wang Xun Lei Xun Lei Xun Lei Xun Lei |
| author_sort | Yangchang Zhang |
| collection | DOAJ |
| description | BackgroundCausal research concerning the consumption of tea and the risk of chronic kidney disease (CKD) is limited. This study identified the potential causal effects of tea intake on CKD, the estimated glomerular filtration rate (eGFR), and albuminuria.MethodsGenome-wide association studies (GWASs) from UK Biobank were able to identify single-nucleotide polymorphisms (SNPs) associated with an extra cup of tea each day. The summary statistics for the kidney function from the CKDGen consortium include 11,765 participants (12,385 cases of CKD) and 54,116 participants for the urinary albumin-to-creatinine ratio who were mostly of European descent. A two-sample Mendelian randomization (MR) analysis was performed to test the relationship between the selected SNPs and the risk of CKD.ResultsA total of 2,672 SNPs associated with tea consumption (p < 5 × 10–8) were found, 45 of which were independent and usable in CKDGen. Drinking more cups of tea per day indicates a protective effect for CKD G3-G5 [odds ratio (OR) = 0.803; p = 0.004] and increases eGFR (β = 0.019 log ml/min/1.73 m2 per cup per day; p = 2.21 × 10–5). Excluding two SNPs responsible for directional heterogeneity (Cochran Q p = 0.02), a high consumption of tea was also negatively correlated with a lower risk of albuminuria (OR = 0.758; p = 0.002).ConclusionFrom the perspective of genes, causal relationships exist between daily extra cup of tea and the reduced risk of CKD and albuminuria and increased eGFR. |
| first_indexed | 2024-12-13T10:20:52Z |
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| id | doaj.art-34b28f6719e54583a18ef677386685c9 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-13T10:20:52Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-34b28f6719e54583a18ef677386685c92022-12-21T23:51:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-03-01910.3389/fnut.2022.801591801591Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization StudyYangchang Zhang0Yangchang Zhang1Yangchang Zhang2Yangchang Zhang3Yang Xiong4Shisi Shen5Jialu Yang6Jialu Yang7Jialu Yang8Wei Wang9Wei Wang10Wei Wang11Tingting Wu12Li Chen13Qiuhua Yu14Hangjia Zuo15Xu Wang16Xu Wang17Xu Wang18Xun Lei19Xun Lei20Xun Lei21Xun Lei22School of Public Health and Management, Chongqing Medical University, Chongqing, ChinaResearch Center for Medicine and Social Development, Chongqing Medical University, Chongqing, ChinaThe Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Public Health Security, Chongqing Medical University, Chongqing, ChinaThe West China Hospital, Sichuan University, Chengdu, ChinaThe First School of Clinical Medicine, Chongqing Medical University, Chongqing, ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing, ChinaResearch Center for Medicine and Social Development, Chongqing Medical University, Chongqing, ChinaThe Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing, ChinaResearch Center for Medicine and Social Development, Chongqing Medical University, Chongqing, ChinaThe Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, ChinaChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, ChinaSchool of Public Health & Institute of Child and Adolescent Health, Peking University, Beijing, ChinaDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaThe First School of Clinical Medicine, Chongqing Medical University, Chongqing, ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing, ChinaResearch Center for Medicine and Social Development, Chongqing Medical University, Chongqing, ChinaThe Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, ChinaSchool of Public Health and Management, Chongqing Medical University, Chongqing, ChinaResearch Center for Medicine and Social Development, Chongqing Medical University, Chongqing, ChinaThe Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Public Health Security, Chongqing Medical University, Chongqing, ChinaBackgroundCausal research concerning the consumption of tea and the risk of chronic kidney disease (CKD) is limited. This study identified the potential causal effects of tea intake on CKD, the estimated glomerular filtration rate (eGFR), and albuminuria.MethodsGenome-wide association studies (GWASs) from UK Biobank were able to identify single-nucleotide polymorphisms (SNPs) associated with an extra cup of tea each day. The summary statistics for the kidney function from the CKDGen consortium include 11,765 participants (12,385 cases of CKD) and 54,116 participants for the urinary albumin-to-creatinine ratio who were mostly of European descent. A two-sample Mendelian randomization (MR) analysis was performed to test the relationship between the selected SNPs and the risk of CKD.ResultsA total of 2,672 SNPs associated with tea consumption (p < 5 × 10–8) were found, 45 of which were independent and usable in CKDGen. Drinking more cups of tea per day indicates a protective effect for CKD G3-G5 [odds ratio (OR) = 0.803; p = 0.004] and increases eGFR (β = 0.019 log ml/min/1.73 m2 per cup per day; p = 2.21 × 10–5). Excluding two SNPs responsible for directional heterogeneity (Cochran Q p = 0.02), a high consumption of tea was also negatively correlated with a lower risk of albuminuria (OR = 0.758; p = 0.002).ConclusionFrom the perspective of genes, causal relationships exist between daily extra cup of tea and the reduced risk of CKD and albuminuria and increased eGFR.https://www.frontiersin.org/articles/10.3389/fnut.2022.801591/fulltea consumptionchronic kidney disease (CKD)SNPsalbuminuriaMendelian randomization |
| spellingShingle | Yangchang Zhang Yangchang Zhang Yangchang Zhang Yangchang Zhang Yang Xiong Shisi Shen Jialu Yang Jialu Yang Jialu Yang Wei Wang Wei Wang Wei Wang Tingting Wu Li Chen Qiuhua Yu Hangjia Zuo Xu Wang Xu Wang Xu Wang Xun Lei Xun Lei Xun Lei Xun Lei Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study Frontiers in Nutrition tea consumption chronic kidney disease (CKD) SNPs albuminuria Mendelian randomization |
| title | Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study |
| title_full | Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study |
| title_fullStr | Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study |
| title_full_unstemmed | Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study |
| title_short | Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study |
| title_sort | causal association between tea consumption and kidney function a mendelian randomization study |
| topic | tea consumption chronic kidney disease (CKD) SNPs albuminuria Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.801591/full |
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