SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

The underlying mechanisms of thymocyte development and lineage determination remain incompletely understood, and the emerging evidences demonstrated that RNA binding proteins (RBPs) are deeply involved in governing T cell fate in thymus. Serine/arginine-rich splicing factor 1 (SRSF1), as a classical...

Full description

Bibliographic Details
Main Authors: Ce Ji, Li Bao, Shunzong Yuan, Zhihong Qi, Fang Wang, Menghao You, Guotao Yu, Jingjing Liu, Xiao Cui, Zhao Wang, Juanjuan Liu, Wenhui Guo, Mingxia Feng, Feng Chen, Youmin Kang, Shuyang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
SRSF1
thymocyte
lineage choice
CD8+ T cell
Runx3
development
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.838719/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.838719/full

Similar Items