SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

The underlying mechanisms of thymocyte development and lineage determination remain incompletely understood, and the emerging evidences demonstrated that RNA binding proteins (RBPs) are deeply involved in governing T cell fate in thymus. Serine/arginine-rich splicing factor 1 (SRSF1), as a classical...

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Détails bibliographiques
Auteurs principaux: Ce Ji, Li Bao, Shunzong Yuan, Zhihong Qi, Fang Wang, Menghao You, Guotao Yu, Jingjing Liu, Xiao Cui, Zhao Wang, Juanjuan Liu, Wenhui Guo, Mingxia Feng, Feng Chen, Youmin Kang, Shuyang Yu
Format: Article
Langue:English
Publié: Frontiers Media S.A. 2022-01-01
Collection:Frontiers in Immunology
Sujets:
SRSF1
thymocyte
lineage choice
CD8+ T cell
Runx3
development
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fimmu.2022.838719/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.838719/full

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