In vitro analysis of anti-HPA-1a dependent platelet phagocytosis and its inhibition using a new whole blood phagocytosis assay (WHOPPA)

In vitro analysis of anti-HPA-1a dependent platelet phagocytosis and its inhibition using a new whole blood phagocytosis assay (WHOPPA)

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a serious bleeding condition mostly caused by the reaction between maternal anti-HPA-1a antibodies and fetal platelets. This reaction leads to Fc-dependent platelet phagocytosis. Although several serological methods have been developed to ide...

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Bibliographic Details
Main Authors: Paula Ames, Nelli Baal, Martin Speckmann, Gabriela Michel, Judith Ratke, Christina Klesser, Nina Cooper, Daisuke Takahashi, Behnaz Bayat, Gregor Bein, Sentot Santoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
platelets
FNAIT
HPA-1a
phagocytosis
monocytes
FcγR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1283704/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1283704/full

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