Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration of basal dendrites. Sema3F and Sema3A signal through distinct holorecep...

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Bibliographic Details
Main Authors: Eleftheria Koropouli, Qiang Wang, Rebeca Mejías, Randal Hand, Tao Wang, David D Ginty, Alex L Kolodkin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
neuropilins
neuropilin-2
Sema3F
palmitoylation
palmitoyl acyltransferases
cortical neurons
Online Access:https://elifesciences.org/articles/83217

Internet

https://elifesciences.org/articles/83217

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