Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC

Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC

Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR i...

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Bibliographic Details
Main Authors: Andreas Kroh, Jeanette Walter, Athanassios Fragoulis, Diana Möckel, Twan Lammers, Fabian Kiessling, Julia Andruszkow, Christian Preisinger, Maren Egbert, Long Jiao, Roman M. Eickhoff, Daniel Heise, Nikolaus Berndt, Thorsten Cramer, Ulf Peter Neumann, Antje Egners, Tom Florian Ulmer
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Hepatocellular carcinoma
Nonalcoholic steatohepatitis
mTOR
Liver metabolism
Metabolic reprogramming
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000696

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http://www.sciencedirect.com/science/article/pii/S1476558623000696

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