From structural design to delivery: mRNA therapeutics for cancer immunotherapy

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority in expressing all sequence‐known proteins in vivo. In particular, with a small dosage of delivered mRNA, antigen‐presenting cells (APCs) can synthesize mutant neo‐antigens and mult...

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Bibliographic Details
Main Authors: Feng Zhou, Lujia Huang, Shiqin Li, Wenfang Yang, Fangmin Chen, Zhixiong Cai, Xiaolong Liu, Wujun Xu, Vesa‐Pekka Lehto, Ulrich Lächelt, Rongqin Huang, Yang Shi, Twan Lammers, Wei Tao, Zhi Ping Xu, Ernst Wagner, Zhiai Xu, Haijun Yu
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Exploration
Subjects:
cancer immunotherapy
cell‐targeted delivery
mRNA design
mRNA therapeutics
organ‐specific delivery
Online Access:https://doi.org/10.1002/EXP.20210146

Internet

https://doi.org/10.1002/EXP.20210146

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